Synthesis of (2S,3S)-3-Aroyl Pyroglutamic Acid Amides
نویسندگان
چکیده
منابع مشابه
[Stereoselective synthesis of polyhydroxylated amines using (S)-pyroglutamic acid derivatives].
Naturally occurring polyhydroxylated amines such as (+)-1-deoxynojirimycin, polyoxamic acid, anisomycin, (-)swainsonine, and alexine stereoisomers, which have interesting biological activities including glucosidase- and mannosidase-inhibitory activity, immunoregulatory activity, and antibacterial effects, were synthesized stereoselectively starting from (S)-pyroglutamic acid derivatives. α,β-Un...
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A microsomal system is described which catalyzes the formation of fatty acid amides of ethanolamine and of several pharmacologically active amines. Although the system has no dependance on external energy sources and has a high K, for the amine substrate, it has several characteristics which differ markedly from an amide hydrolytic system in the microsomes. A possible mechanism for the formatio...
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In the reaction of 5-arylidene-2,4-dioxothiazolidine-3-acetic acid chloride with 1,2,4-triazole, 1,2,4-triazoline-5-one and 1,2,4-triazoline-5-thione, the new corresponding 5-arylidene-2,4-dioxothiazolidine-3-acetic acid amides (5-16) were obtained. Compounds 6, 14 i 15 were investigated in vitro for their antioxidant activity.
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Amide is a derivative of carboxylic acids with a general formula of RCONH2, where R is hydrogen or an alkyl or an aryl radical. The amides are abundant in life, as proteins play a vital role in almost all biological processes. They present in many pharmaceutical substances. An in-depth analysis of the Comprehensive Medicinal Chemistry database reveals that the carboxamide group appears in more ...
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A novel synthesis of anhydrides from twisted amides is reported. Sc(OTf)3 catalysis in the presence of water is used to synthesize anhydrides in one step from amides without external nucleophiles. Mechanistic studies indicate that the coordination of the catalyst is critical to induce the challenging N-C activation step. This process further highlights the utility of twisted amides in organic s...
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ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/ecsoc-24-08377